Senior Computational Biologist (CRUK)

The University of Manchester
11 Sep 2019
18 Sep 2019
Contract Type
Full Time

Senior Computational Biologist

  • Salary in the range of ??24,776 - ??36,000 per annum (dependent upon experience)
  • Job Ref: MI/19/40
  • Duration of role: Fixed term until 31st March 2022

About the role:

We are currently looking for a Senior Computational Biologist to join the expanding Bioinformatics and Biostatistics (BBS) Team within the Clinical and Experimental Pharmacology (CEP) group and the newly established Manchester Centre for Cancer Biomarker Sciences (MCCBS) led by Prof Caroline Dive CBE. The MCCBS has an international reputation for liquid biomarkers and one aspect of this Team's role will be to evaluate data from DNA and/or RNA derived from patient blood samples to derive robust classifiers that support cancer patient treatment management.

Pivotal goals of the MCCBS are to develop biomarkers that improve cancer detection, aid prognosis, predict and monitor patient responses to therapy with an overall goal to facilitate cancer precision medicine. A flagship project of the MCCBS is TARGET, a clinical protocol in which Phase I clinical trial patients provide a blood sample at baseline and we explore whether ctDNA profile can support selection of the best clinical trial available for each patient. Bioinformatics analysis of TARGET derived clinical samples will be the first priority for this post holder working closely with the Nucleic Acids Biomarkers team within the centre. There will also be opportunities within the BBS team to develop novel algorithms and methodologies.

About you:

You should have a degree in computational biology, mathematics or related discipline (or equivalent) plus significant relevant experience analysing genomics data or a relevant postgraduate degree. Additionally you should have substantial experience writing complex code in at least one of the following: Perl, Python, R, Matlab, C, or C++.

Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute (), an Institute of The University of Manchester (), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (), the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.

We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK MI Paterson Building) in South Manchester (), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials.

The Institute has access to outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry.

Additional Information:

On the 26th April 2017 The Paterson Building, which housed most of the Cancer Research UK (CRUK) Manchester Institute, caught fire resulting in significant damage. We shall be rebuilding our world-class research facilities and we would like to make you aware that in the meantime, the primary place of work for this position will be at the internationally-renowned life sciences campus at Alderley Park, which has excellent facilities to carry out research. We anticipate that this will be for a few years, after which we will return to our original site in Withington, Manchester, next to The Christie NHS Foundation Trust (Wilmslow Road, M20 4BX).

Please apply on the CRUK website using the following link:

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies

Enquiries about vacancy shortlisting and interviews:

Name: Dr Alastair Kerr, BBS Team Lead


Technical support:



General enquiries:



This vacancy will close for applications at midnight on the closing date

Further Particulars and Job Description

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